ABSTRACT
Objective To study the association between Essen stroke risk score (ESRS) and coronary heart disease (CHD).Methods One hundred and forty-six patients who underwent coronary angiography in our hospital from July 1,2015 to December 31,2016 were divided into CHD group (n=105) with their stenosis ≥50％ and non-CHD group (n=41) with their stenosis ＜50％.Their clinical,laboratory and coronary angiography data were recorded and analyzed by univariate logistic regression analysis and multivariate logistic regression analysis respectively.ROC curve of ESRS was plotted for diagnosing CHD.Results The age was significantly older,the incidence of hypertension,diabetes mellitus and myocardial infarction,the ESRS and fasting blood glucose level were significantly higher in CHD group than in non-CHD group (P＜0.05,P＜0.01).The age,history of smoking and alcohol drinking,and the incidence of abnormal blood lipid,AF,other heart diseases,peripheral artery disease,ischemic stroke or the serum levels of TIA,TC,TG,LDL-C,HDL-C and uric acid were significantly different between CHD group and non-CHD group (P＞0.05).Multivariate logistic regression analysis showed that ESRS was an independent risk factor for CHD (OR=2.070,95％CI:1.473-2.908,P＜0.01).The area under the ROC curve of ESRS for diagnosing CHD was 0.743 (95％CI:0.651-0.834,P＜0.01).The Youden's index was the highest when the ESRS was 2 with a sensitivity of 80.95％ and a specificity of 58.54％.Conclusion ESRS is related with CHD and can thus predict the occurrence of CHD.It is necessary to make an overall assessment of CHD when the ESRS is ≥2.
ABSTRACT
Objective To establish a quantitative analysis method for determining 99mTc-HYNIC-PEG4-E[PEG4-c(RGDfK)]2 (99mTc-3PRGD2,a radioactive tumor agent)byγcounter, and to investigate the distribution of 99mTc-3PRGD2 in mice bearing with lung carcinoma xenograft. Methods The mice were divided into 4 normal groups and one blocking peptide group(control group). The 99mTc-3PRGD2(8μg/kg)was injected to mice bearing with lung carcinoma xenograft through the tail intravenous administration. Tissues of the normal mice were taken at 0.5,1,2 and 4 h. The control group were treated by 3PRGD2 and 99mTc-3PRGD2. The control mice were injected with the 3PRGD2 saline solution(2.5 mg/ml,0.2 ml)at 0.5 h earlier before the injection of 99mTc-3PRGD2. The tu?mor and organ tissues of the control mice were taken at 2 h. The radioactivity was detected by Gamma Counter. Results The radioac?tivity of 99mTc-3PRGD2 detected was high in the tumor and very low in brain. In addition,high radioactivity in kidneys and bladder sug?gested that the drug excreted by renal. Conclusion The results proved that the blocking peptide can competitively inhibit the combi?nation of 99mTc-3PRGD2 and integrinαvβ3 receptors.